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๊ฐœ๋ฐœ์ž 29

siRNA, RNAi, off-target effect

RNAi(RNA interference) siRNA(short interfering RNA)๋ผ ๋ถˆ๋ฆฌ๋Š” 12~21 mer์˜ dsRNA์— ์˜ํ•ด ์„œ์—ด ํŠน์ด์ ์œผ๋กœ ์œ ์ „์ž ๋ฐœํ˜„์ด ์–ต์ œ๋˜๋Š” ํ˜„์ƒ --> RNA ๊ฐ„์„ญ gene silencing by RNAi RNA ๊ฐ„์„ญ์„ ์ด์šฉํ•ด ํŠน์ • ์œ ์ „์ž์˜ ํ™œ์„ฑ์„ ์–ต์ œํ•  ์ˆ˜ ์žˆ์Œ ํ‘œ์  mRNA์™€ ์ƒ๋ณด์  ๊ด€๊ณ„์— ์žˆ๋Š” ์ด์ค‘๊ฐ€๋‹ฅ RNA ๋ฅผ ์„ธํฌ์— ๋„์ž…ํ•˜๋Š” ๋ฐฉ๋ฒ•์œผ๋กœ ์–ต์ œ ๊ฐ€๋Šฅ ๋‹จ์ : ํšจ๊ณผ๊ฐ€ ์ผ์‹œ์ ์ผ ์ˆ˜ ์žˆ์œผ๋ฉฐ, ๋‹ค๋ฅธ ์œ ์ „์ž ๋ฐœํ˜„๋„ ์–ต์ œํ•  ์ˆ˜ ์žˆ์Œ siRNA(short interfering RNA) off-target effect ์ค„์—ฌ์„œ design ํ•ด์•ผํ•จ Off-target effect siRNA๋ฅผ ์ด์šฉํ•œ RNAi์˜ ๋ถ€์ž‘์šฉ, ๋‹ค๋ฅธ ์œ ์ „์ž ๋ฐœํ˜„๋„ ์–ต์ œ๋˜๋Š” ํ˜„์ƒ https://www.ibri..

Bioinfomatics 2021.02.03

[Python] Pandas dataframe ๊ฒฐํ•ฉ, ์กฐ์ธ, ๋ณ‘ํ•ฉ(Join, Merge)

Join 1. ์˜ˆ์‹œ ๋ฐ์ดํ„ฐํ”„๋ ˆ์ž„ ์ƒ์„ฑ import pandas as pd df = pd.DataFrame({'key': ['K0', 'K1', 'K2', 'K3', 'K4', 'K5'], 'A': ['A0', 'A1', 'A2', 'A3', 'A4', 'A5']}) other = pd.DataFrame({'key': ['K0', 'K1', 'K2'], 'B': ['B0', 'B1', 'B2']}) 2. ์—ด์˜ Index ์ง€์ •ํ•ด์„œ Join df.join(other, lsuffix = '_caller', rsuffix = '_other') 3. Key๋ฅผ index๋กœ ์ง€์ •ํ•ด Join df.set_index('key').join(other.set_index('key')) 4. join ๋ฉ”์†Œ๋“œ์˜ parameter ..

[Python] Pandas Dataframe ์—ด์— ์–ด๋–ค ๋ฐ์ดํ„ฐ ์žˆ๋Š”์ง€ value ํ™•์ธ, ๋ฐ์ดํ„ฐ ๋ณ„๋กœ ๊ฐœ์ˆ˜ ์„ธ๊ธฐ, ์ค‘๋ณต๊ฐ’ ํ™•์ธ, ์œ ์ผํ•œ(์œ ๋‹ˆํฌํ•œ) ๊ฐ’ ์ฐพ๊ธฐ

df.unique() ์œ„์˜ ๋ฐ์ดํ„ฐํ”„๋ ˆ์ž„์€ cell_line์— ๋Œ€ํ•œ ๋‚ด ์˜ˆ์‹œ ๋ฐ์ดํ„ฐ์ด๋‹ค. ์ด์ œ ์ด cell_lien ๋ฐ์ดํ„ฐ์—์„œ ์œ ๋‹ˆํฌํ•œ ๊ฐ’์„ ์ฐพ์•„๋ณผ ๊ฒƒ์ด๋‹ค. 1. ๋ฐ์ดํ„ฐํ”„๋ ˆ์ž„์—์„œ ์ค‘๋ณต์„ ์ œ๊ฑฐํ•˜์ง€ ์•Š๊ณ  ๊ฐ’ ํ™•์ธ cell_line = f['epigenomes_with_experimental_evidence'].values # values = df[์ปฌ๋Ÿผ๋ช…].values ์œ„์˜ ์ฝ”๋“œ๋ฅผ ์‹คํ–‰ํ•˜๋ฉด arrayํ˜•ํƒœ๋กœ ๋ชจ๋“  ๊ฐ’์ด ์ถœ๋ ฅ๋œ๋‹ค. 2. ๋ฐ์ดํ„ฐํ”„๋ ˆ์ž„์—์„œ ๊ฐ ์š”์†Œ๋ณ„๋กœ ๋ช‡๊ฐœ์˜ ๋ฐ์ดํ„ฐ๊ฐ€ ์žˆ๋Š”์ง€ ํ™•์ธ f['epigenomes_with_experimental_evidence'].value_counts() # df[์ปฌ๋Ÿผ๋ช…].value_counts() 3. ๋ฐ์ดํ„ฐํ”„๋ ˆ์ž„์—์„œ ์ค‘๋ณต์„ ์ œ๊ฑฐํ•˜๊ณ  ์œ ๋‹ˆํฌํ•œ ๊ฐ’ ํ™•์ธ f['epigenome..

Unit test๋ž€? ํ…Œ์ŠคํŠธ ์ฝ”๋“œ ์ž‘์„ฑํ•ด์•ผ ํ•˜๋Š” ์ด์œ , ๊ฐ„๋‹จํ•œ ์˜ˆ์ œ (+ GitHub)

Unit test(๋‹จ์œ„ ํ…Œ์ŠคํŠธ)๋ž€? ์ „์ฒด ์ฝ”๋“œ ์ค‘ ์ž‘์€ ๋ถ€๋ถ„์„ ํ…Œ์ŠคํŠธํ•˜๋Š” ์ฝ”๋“œ ํ•จ์ˆ˜ ํ•˜๋‚˜ํ•˜๋‚˜ ๊ฐœ๋ณ„๋กœ ํ…Œ์ŠคํŠธ ์ฝ”๋“œ๋ฅผ ์ž‘์„ฑํ•˜๋Š” ๊ฒƒ ๋ฒ„๊ทธ๊ฐ€ ์žˆ๋Š”์ง€ ์—†๋Š”์ง€ ์ฒดํฌํ•  ์ˆ˜ ์žˆ์Œ ์–ด๋– ํ•œ ๋ถ€๋ถ„์— ๋ฌธ์ œ๊ฐ€ ์žˆ๊ณ , ๊ณ ์น  ๋ถ€๋ถ„์ด ์–ด๋””์ธ์ง€ ๋ช…ํ™•ํ•˜๊ฒŒ ์•Œ ์ˆ˜ ์žˆ๊ฒŒ ์ž‘์„ฑํ•ด์•ผํ•จ ๊ฐ„๋‹จํ•˜๊ณ  ๋ช…ํ™•ํ•ด์•ผํ•จ Unit test ํ•„์š”์„ฑ ๋ฒ„๊ทธ๊ฐ€ ์žˆ๋Š”์ง€ ์—†๋Š”์ง€ ์ฒดํฌํ•˜๋Š” ์œ ๋‹› ํ…Œ์ŠคํŠธ ๋งŒ๋“ค์–ด ๋‘ ์œผ๋กœ์จ ๋ฌธ์ œ ์‰ฝ๊ฒŒ ํ•ด๊ฒฐ ๊ฐ€๋Šฅ ํ…Œ์ŠคํŠธ ์ฝ”๋“œ๊ฐ€ ์ž‘์„ฑ์ด ์ž˜ ๋˜์–ด์žˆ์œผ๋ฉด ์–ด๋””์— ๋ฌธ์ œ๊ฐ€ ์žˆ๊ณ  ์–ด๋””๋ฅผ ๊ณ ์ณ์•ผ ํ• ์ง€ ๋ช…ํ™•ํ•˜๊ฒŒ ์•Œ ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ ๊ฐœ๋ฐœ ์ค‘ ๋ฏธ๋ฆฌ ๋ฌธ์ œ ํŒŒ์•… ๊ฐ€๋Šฅ ๋ณต์žกํ•œ ๋ฆฌ์†Œ์Šค๋“ค์„ ๊ฐ€์ ธ์˜ค์ง€ ์•Š๊ณ  ์‰ฝ๊ฒŒ ์ฝ”๋“œ ์‹คํ–‰์‹œ์ผœ๋ณด๊ธฐ ์œ„ํ•ด ์ž‘์„ฑ ๋ฒ„๊ทธ๋ฅผ ์ดˆ๊ธฐ์— ์žก์•„๋‚ด๊ธฐ ์ข‹์Œ ๊ฐ„๋‹จํ•œ ์˜ˆ์ œ API๋ฅผ ์ด์šฉํ•˜๋Š” ์˜ˆ์ œ์— ๋Œ€ํ•ด test code ์ž‘์„ฑ Ensemble_REST_API_Test.ipyn..

Git 2021.01.16
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